Bio Ebook

English | 75 pages | PDF | 10.05 MB
Scientific American (informally abbreviated to SciAm) is a popular science magazine published since August 28, 1845, which according to the magazine makes it the oldest continuously published magazine in the United States. It brings articles about new and innovative research to the amateur and lay audience.
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Modern science is increasingly collaborative, as signaled by rising numbers of coauthored papers, papers with international coauthors, and multi-investigator grants. Historically, scientific collaborations were carried out by scientists in the same physical location—the Manhattan Project of the 1940s, for example, involved thousands of scientists gathered on a remote plateau in Los Alamos, New Mexico.

Today, information and communication technologies allow cooperation among scientists from far-flung institutions and different disciplines. Scientific Collaboration on the Internet provides both broad and in-depth views of how new technology is enabling novel kinds of science and engineering collaboration. The book offers commentary from notable experts in the field along with case studies of large-scale collaborative projects, past and ongoing.

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The world's leading journal of original scientific research, global news, and commentary.

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This book reviews actual trends in modern biotechnology. Its aim is to cover all aspects of this interdisciplinary technology where knowledge, methods and expertise are required for chemistry, biochemistry, microbiology, genetics, chemical engineering and computer science. Special volumes are dedicated to selected topics which focus on new biotechnological products and new processes for their synthesis and purification. They give the state-of-the-art of a topic in a comprehensive way thus being a valuable source for the next 3 - 5 years. It also discusses new discoveries and applications. Special volumes are edited by well known guest editors who invite reputed authors for the review articles in their state-of-the-art of a Click here to download or Click here to download

Description: The series Structure and Bonding publishes critical reviews on topics of research concerned with chemical structure and bonding. The scope of the series spans the entire Periodic Table and addresses structure and bonding issues associated with all of the elements. It also focuses attention on new and developing areas of modern structural and theoretical chemistry such as nanostructures, molecular electronics, designed molecular solids, surfaces, metal clusters and supramolecular structures. Physical and spectroscopic techniques used to determine, examine and model structures fall within the purview of Structure and Bonding to the extent that the focus is on the scientific results obtained and not on specialist information concerning the techniques themselves. Issues associated with the development of bonding models and generalizations that illuminate the reactivity pathways and rates of chemical processes are also relevant. Click here to download or Click here to download

Ovarian carcinoma continues to be responsible for more deaths than all other gynecologic malignancies combined, due to a continued inability to achieve detection of early (rather than advanced) stage disease and the lack of effective tumor-specific therapeutics. Ovarian carcinogenesis, invasion, and metastatic dissemination require a complex cascade of interrelated genetic, molecular, and biochemical events that regulate the neoplastic transition of normal ovarian surface epithelium.This updated second edition includes exciting new advances in ovarian cancer detection and treatment and provides an analysis of current research into aspects of malignant transformation, growth control, and metastasis. A more detailed understanding of these processes may ultimately translate into the development of novel approaches for the detection and control of ovarian .
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Cell Therapy: cGMP Facilities and Manufacturing is the source for a complete discussion of facility design and operation with practical approaches to a variety of day-to-day activities, such as staff training and competency, cleaning procedures, and environmental monitoring. This in-depth book also includes detailed reviews of quality, the framework of regulations, and professional standards. It meets a previously unmet need for a thorough facility-focused resource, Cell Therapy: cGMP Facilities and Manufacturing will be an important addition to the cell therapy professional’s library.
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Within the classic renin-angiotensin endocrine system, the enzyme renin is produced in the kidney and upon stimulation for its release, it acts upon circulating angiotensinogen which is produced in the liver. The resultant decapeptide angioteinsin I loses its terminal two peptides upon its circulation through the lung by the angiotensin converting enzyme to form the powerful pressor decapeptide angiotensin II which promotes potent vasoconstriction, stimulates the release of aldosterone from the adrenal gland and, in turn, the retention of sodium and water by the kidney.

Until recently, there has been much research concerning local renin angiotensin systems functioning within such organs as the heart, blood vessels, kidney, brain, and others. In addition, research has shown that some of these organs also seem to produce locally the steroidal hormone aldosterone. This very important area of research has now achieved major clinical attention because these local systems seem to account for such major biological actions as mitogenesis, cellular hypertrophy, fibrosis, apoptosis, and inflammation within those organs. Moreover, further research has demonstrated still more complicated aspects to the metabolic events associated with the cascade of hormonal substances that result from the biogenesis of the angiotensins. The clinical implications of these events are of great clinical significance and also important.
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Description: The book The DNA Damage Response: Implications on Cancer Formation and Treatment brings together a great collection of review articles. The articles have been written by a group of experts who have a deep knowledge of the recent advances in the fields of DNA damage signalling and repair and their implications in carcinogenesis.

The book is divided into chapters that deal with the elaborate surveillance system and repair mechanisms used by cells to suppress mutagenic lesions to avoid cancer. It provides snapshots of:
* current understanding of DNA damage signalling,
* cell cycle checkpoints,
* some of the major DNA repair pathways,
* functional links between DNA damage,
* genomic instability and cancer,
* implications of DNA damage for the development of new treatment modalities for cancer.
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Pharmacology, Fourth Edition enables rapid review and assimilation of large amounts of complex information about the essentials of medical pharmacology. Clear, sequential pictures of mechanisms of action actually show students how drugs work, instead of just telling them. As in previous editions, the book features an outline format, over 500 full-color illustrations, cross-references to other volumes in the series, and over 125 review questions. Content has been thoroughly updated, and a new chapter covers toxicology. New to this edition will be a companion Website containing all of the illustrations, fully searchable text, and an interactive question bank.
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Veronika Meyer's book on HPLC is a classic text and remains one of the few titles available on general HPLC. Following on from the success of the previous three editions, this new, fourth edition continues to provide users of HPLC in industry, government, and service laboratories, as well as postgraduate students, with a unified approach to HPLC and an equal treatment of the theory and practice of this important technique.
The contents of this edition have been revised, expanded and updated. Where available, old literature references have been replaced by recent ones.
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This textbook is intended for undergraduate students (juniors or seniors) in Biomedical Engineering, with the main goal of helping these students learn about classical control theory and its application in physiological systems. In addition, students should be able to apply the Laboratory Virtual Instrumentation Engineering Workbench (LabVIEW) Controls and Simulation Modules to mammalian physiology. The first four chapters review previous work on differential equations for electrical and mechanical systems. Chapters 5 through 8 present the general types and characteristics of feedback control systems and foot locus, frequency response, and analysis of stability and margins. Chapters 9 through 12 cover basic LabVIEW programming, the control module with its pallets, and the simulation module with its pallets. Chapters 13 through 17 present various physiological models with several LabVIEW control analyses. These chapters cover control of the heart (heart rate, stroke volume, and cardiac output), the vestibular system and its role in governing equilibrium and perceived orientation, vestibulo-ocular reflex in stabilizing an image on the surface of the retina during head movement, mechanical control models of human gait (walking
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This ABC is a concise, highly illustrated introduction to genetic mechanisms involved in inherited disorders. The new edition has been extensively updated with new and revised chapters to encompass rapid advances in the field. Basic genetic concepts are explained along with the application of new technologies in clinical practice. Information on relevant web sites are also included along with recommended texts for further reading.

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Product Description
First volume in a series of undergraduate textbooks. Covers a number of examples of transcription systems for eukaryotes and prokaryotes. Indicates methods for studying and surveying transcription. Features study objectives, halftone illustrations and review questions. Expanded-outline format. Softcover, hardcover available.

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John R. Crowther provides today's premier practical guide to the understanding and application of ELISA. This Edition enlarges on charting methods for assessing the indirect ELISA, ruggedness and robustness of tests, aspects of kit use and validation, and internal quality control and external quality management of data. The author describes each method in great detail to ensure experimental success and includes advice on equipment choice, maintenance, and calibration. Wherever possible, helpful written explanations are provided along with copious diagrams.

With its numerous worked examples, detailed instructions, and extensive illustrations, The ELISA Guidebook, Second Edition offers a powerful synthesis of all the basic concepts and practical experimental details investigators need to understand, develop, and apply ELISA methodology successfully in day-to-day basic and clinical research.

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Following the considerable success of the first edition of Plant Virology Protocols, this exciting new edition covers the many new techniques that are now applied to the examination and understanding of plant viruses. Each section of Plant Virology Protocols, Second Edition presents the most novel methods and protocols to allow researchers more effective approaches to study plant viruses. The many subjects covered in this important new edition range from techniques for investigating viral nucleic acid sequence, protein analysis and investigation of protein function, techniques for microscopy/GFP visualization and analysis/protein tagging/generation of infectious clones and other such tools, as well as areas of genomics and interactions with host factors and plant-based studies. Plant Virology Protocols, Second Edition: From viral sequence to protein function is indispensable to laboratory investigators studying plant viruses.

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Title: Drug-Drug Interactions in Pharmaceutical Development

Author(s): Binghe Wang

Series: Wiley Series in Drug Discovery and Development

Publisher: Wiley-Interscience

ISBN: 0471794414

Publication: 2007

Pages: 244

Description: Drug-Drug Interactions in Pharmaceutical Development comprehensively reviews the relevant science, industrial practice, and regulatory agency positions on drug-drug interactions. It focuses on the evaluation of potential drug-drug interactions, allowing researchers to address risk factors before a drug is put to market. The book covers both clinical and nonclinical aspects for understanding drug-drug interactions as well as in vitro and in vivo studies for use in studying interactions at the drug discovery stage.

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Title: Gene Cloning

Author(s): Lodge/Lund/Minc

Series: n/a

Publisher: Taylor & Francis

ISBN: 0748765344

Publication: 2006

Pages: 462

Description: Cloning genes has become such a routine part of molecular biology, and the approaches to it so many and diverse, undergraduates can easily be overwhelmed. Gene Cloning is designed to give the undergraduate a broad overview of the subject, guiding the student through the basic elements involved and their utility, and further through the interpretation of results and datasets. Having understood the basic processes, the reader is introduced to some of the most common uses of gene cloning, from applications with more research-oriented goals to practical applications in biotechnology in medicine. Clearly presented in two-colour text, Gene Cloning is essential reading for undergraduates in the molecular life sciences.

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Title: Gene Regulation

Author(s): David Latchman

Series: BIOS Advanced Text

Publisher: Taylor & Francis

ISBN: 0415365104

Publication: 2005

Pages: 374

Description: Gene regulation is an essential process in the development and maintenance of a healthy body, and as such is a central focus in both basic science and medical research. Gene Regulation, Fifth Edition, provides the student with a clear, up-to-date description of gene regulation in eukaryotes, distilling the vast and complex primary literature into a concise overview. For this fifth edition, in addition to extensive updating of existing material, sections on large-scale methodologies have been expanded, and a new section included on regulation by small interfering RNAs. More detail has been added on the role of multi-protein complexes in transcriptional activation and the discussion of the regulation of transcription factor activity by specific modifications to include acetylation and ubiquitination as well as phosphorylation. The final chapter on gene regulation and human disease now includes additional novel examples, such as RNA edition in motor neurone disease, role of the transcriptional co-activator CBP in Alzheimer's disease and PML-RAR involvement in acute promyelocytic leukemia.

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