This book deals with the role of water in cell function. Though long recognized to be central to cell function, water’s role has not received the attention lately that it deserves. This book brings the role of water front and central. It presents the most recent work of the leading authorities on the subject, culminating in a series of sometimes astonishing observations. Water is a subject of interest to virtually everyone. It is becoming increasingly important in health therapy, in the environment, in chemistry and physics, and certainly in cells. Thus, this groundbreaking volume will be of great interest to a broad audience, well beyond those in biology alone. The reader will be richly awarded with insights difficult or impossible to obtain in current textbooks, which generally treat water merely as a background carrier with limited significance.
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The goal of the International Immune-Mediated Diseases: From Theory to Therapy (IMD) Congress is to bring the world’s best immunologists and clinicians to Moscow to participate in plenary sessions, symposia and educational workshops designed to expose basic and clinical immunologists - as well as practicing clinicians - to the newest developments in the field.
The first IMD Congress consisted of eight Plenary Sessions, 40 Symposia and 25 Workshops. The meeting attracted almost 2000 participants and speakers from 15 countries. After the great success of the First IMD Congress, the Organizing Committee decided to convene the meeting every other year and the Second International IMD Congress was held in September 2007. Special attention was given to innovative therapeutic modalities, allergy and asthma, immunodeficiency, tumor and transplant immunology, immunotherapy and vaccines, HIV and infectious diseases, autoimmune diseases, inflammation, immunomonitoring and immunodiagnostics.
This volume includes contributions from the speakers of the Second IMD Congress (September 10-15, 2007; Moscow, Russia) who were eager to share some of the academic and clinical enthusiasm that defines the IMD meetings.This volume summarizes the new developments that made subcellular proteomics a rapidly expanding area. Recent success stories demonstrated that the combination of subcellular prefractionation methods with proteomic analysis is a very potent approach to simplify complex protein extracts from cells or tissues and to detect low abundance proteins. It also made clear that sophisticated strategies encompassing sample preparation, analytics and validation steps were required to fully exploit the potential of subcellular proteomics. Three sections are devoted to the different levels of subcellular organization and their specific methodologies. This is completed by a section on systems biology that deals with the integration of the data derived from these different levels to produce a synthetic description of the cell as a system. A survey of the most advanced technical developments in proteomics is also included, which covers single cell analysis methods, molecular imaging and LC-MALDI. Written by a panel of leading experts in the field, this book represents an unprecedented attempt to reflect state-of-the-art methodology and also to convey both the mode of thinking and the hype of this discipline. This volume should appeal not only to experts in the field and to researchers in disciplines such as cell biology or biochemistry but also to newcomers who wish to learn about the proteomic analysis of subcellular structures. Lastly, it can also serve as a reference guide for teachers, advanced undergraduates and graduate students desiring to learn more about this challenging field.
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